AAPS 2020 Poster: Development of High Drug Load Multiparticulate Beads Using an Extrusion-Spheronization Process

Request a copy of our poster from AAPS 2020 titled, "Development of High Drug Load Multiparticulate Beads Using an Extrusion-Spheronization Process.

During high shear wet massing, changes in impellor torque occur as a result of changes in cohesive forces in the wet powder bed, and can be used to assess end points. However, for these formulations the change in torque was not sensitive enough for end point identification. Optimal end point for extrusion-spheronization reached just before the traditional wet granulation end point.