AAPS 2020 Poster: Improving the Stability of a Spray-Dried Peroxide-Susceptible Drug in Tablets

Download our poster from AAPS 2020 titled, 'Improving the Stability of a Spray-Dried Peroxide-Susceptible Drug in Tablets.'

Compound X (Cmp-X) belongs to the class of PDE-5 inhibitors and is a BCS Class II candidate with equilibrium solubility <3 μg/mL, thus exhibiting a dissolution rate of limited bioavailability. The purpose of this work is to develop an amorphous solid dispersion (ASD) by spray drying and monitor and improve the physical and chemical stability upon storage for developing a successful solid dosage formulation.