AAPS 2019 Poster: Development of a Solubilised Capsule Formulation Using Co-Micronization and Precipitation Inhibition

Presented at AAPS 2019: Both micronization and co-micronization can improve the rate and extent of drug dissolution. However, co-micronization of Drug A with a precipitation inhibitor HPC and further blending with a wetting agent SLS could significantly increase the drug dissolution to achieve a supersaturated state for Drug A. In the presence of a precipitation inhibitor, the solubilized drug was maintained in the metastable over some time with a slow precipitation rate. The addition of a precipitation inhibitor has successfully maintained Drug A in the solubilized form for an extended period allowing greater potential for drug absorption. In vivo studies will be conducted to evaluate the bioavailability of the final formulation. The final results demonstrate the co-micronization process managed to improve the bioavailability of the poorly soluble drug investigated.

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