AAPS 2015 Poster: Rapid Formulation Development and Clinical Testing of Gastro-Retentive Controlled Release Technology to Enable Once-Daily Dosing
26 October 2017
Overview
MK-X had demonstrated poor colonic absorption in dogs and conventional matrix-based controlled release formulations failed to achieve adequate trough concentrations in a human pharmacokinetic (PK) study to support once-daily dosing.
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