Whitepapers , Modified Release , Formulation Development , Translational Pharmaceutics

Alternative Strategies for Development of Modified Release Dosage Forms

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Alternative Strategies for Development of Modified Release Dosage Forms

Overview

Modified-release (MR) formulations are in high demand in today's drug development strategies.

For formulators, they enable drugs to be released in the optimal gastrointestinal (GI) locations to achieve and maintain desirable plasma concentrations for extended periods, avoiding undesirable excursions outside the therapeutic range.

Learn more about our capabilities for modified-release.

Types of modified-release dosage forms we work with:

Modified-release format	Objective	Formulation technology
Gastro-retention	Keep the formulation in the stomach for an extended period to maximize the duration of absorption or therapeutic activity	Swellable tablets (monolithic, bilayer, trilayer)
Gastro-resistant	Prevent release of the drug in the stomach and/or upper gastrointestinal (GI) tract Overcome first-pass metabolism or gastric irritation	Enteric-coated tablets or capsules
Sustained or extended release	Extend the in-vivo release profile of the drug or enable once-daily dosing	Matrix tablets, coated tablets, or multiparticulates
Targeted or controlled delivery	Release the drug at or near the intended site of absorption or action Have either immediate-release or extended-release characteristics Deliver time-, pH-, or microbially-triggered release	Tablets, capsules, or multiparticulates
Biphasic release	Eliminate the need for repeat dosing Provide rapid therapeutic effect from an immediate-release layer and extended dosing from a sustained-release layer	Bilayer tablets or multiparticulates
Pulsatile release	Release the drug as a pulse after a pre-determined lag time, designed according to the body’s circadian rhythm Provide a release mechanism beneficial for drugs where time-dependent dosing is required or those that undergo first-pass metabolism	Bilayer tablets or multiparticulates

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Alternative Strategies for Development of Modified Release Dosage Forms

Modified-release (MR) formulations are in high demand in today's drug development strategies.

Types of modified-release dosage forms we work with:

Download

Solubility enhancement questions? Get answers from our team.

Dr. Andrew Lewis

Dr. Asma Patel

Robert Cornog

Brad Rowe

How to Address Poor Solubility: A Data-Driven Path to Success (Infographic)

Poor Solubility as a Program-Level Risk: How to Make Better Formulation Decisions

Alternative Strategies for Development of Modified Release Dosage Forms

On-Demand: Leveraging Real-Time Clinical Data to Deliver Certainty in Solubility Enhancement and Modified Release Development

Alternative Strategies for Development of Modified Release Dosage Forms

Modified-release (MR) formulations are in high demand in today's drug development strategies.

Types of modified-release dosage forms we work with:

Download

Share

Solubility enhancement questions? Get answers from our team.

Dr. Andrew Lewis

Dr. Asma Patel

Robert Cornog

Brad Rowe

More about our solubility enhancement capabilities

How to Address Poor Solubility: A Data-Driven Path to Success (Infographic)

Poor Solubility as a Program-Level Risk: How to Make Better Formulation Decisions

Alternative Strategies for Development of Modified Release Dosage Forms

On-Demand: Leveraging Real-Time Clinical Data to Deliver Certainty in Solubility Enhancement and Modified Release Development